General Information on Aciphex (Rabeprazole)
This drug is an antacid, anti- ulcer.
Belongs to the class Proton Pump Inhibitors
The IUPAC name is (RS)-2-([4-(3-methoxypropoxy)-3-methylpyridin-2-yl]methylsulfinyl)-1H-benzo[d]imidazole
The brand Aciphex is manufactured by the the Eisai pharmaceutical company, and marketed by Janssen- Cilag.
The other brands available are Pareit, Rabesoft, Rabio and Veloz
This drug is also available in combination with Domperidone, Itopride
Pharmacology
The formula of Aciphex is C18 H12 N3 O3 S
Physical Properties. Aciphex is white to yellow solid, soluble in water and alcohol, dissolves quickly in acid medium
Bound to protein 97%
Metabolizes in Liver by Cytochrome P450, and is excreted in urine.
The half life or the effect of the drug in our body is 1 hour, duration of action is for 24 hours
Hence can be taken once daily
Usage/ Indication and Dosage
Aciphex is available in the following strengths
Aciphex 20 mg and aciphex 40 mg
The appropriate Dosage will be calculated by your physician depending upon your condition
Aciphex is also available in combination with Domperidone, Itopride.
The maximum dose of Aciphex available now is 40 mg
The indications are viz;
Acid peptic disease,
gastric Ulcer,
Duodenal ulcer,
Heartburn,
In GERD gastro-esophageal reflux disease, which is nothing but the feeling of heat burn and sour taste in your throat after you burp, if happens rarely not an issue though, but if happens regularly, then this is the tablet you should be taking.
In H-Pylori infection, along with the anti-biotic you will be given this drug or better results
When taken along with domperidone, itopride this combination promotes digestion and prevents heartburn.
Treatment is usually for 4- 8 weeks, except for conditions like zollinger Ellison disease, where the acid production in the stomach is always high.
Mechanism of Action
Acts by inhibiting/ stopping the release of acid through Proton Pumps present in the stomachs parietal cell, which are responsible for the acid release.
Side/ Adverse effects of Aciphex
Rashes, allergy reaction, if the patient is allergic to rabeprazole and related compounds.
The other un-common undesired effects are drowsiness, headache, nausea, gas trouble, constipation and rarely infection.
Precaution and contra indication
Hypersensitivity
Pediatric age group
Hepatic and renal disease
Pregnancy B
Malignancy
To be used in caution when patients are taking warfarin
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