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General Information on Actos (Pioglitazone HCL)
Tablet Actos (Pioglitazone) is an oral hypoglycemic agent (OHA) also called as Anti-diabetic drug (ADA)
Belongs to the class thiazolidinedione (TZD)
The IUPAC name of pioglitazone is 5-ethyl pyridin-2-yl ethoxy - benzyl thiazolidine-2, 4 - dione
The brand Actos is manufactured by the the Takoda pharmaceuticals North America
The other brands available or Pioglitazone are Glizone (Zydus) Pioz (USV) Zactos (Takeda Mexico)
Actos (pioglitazone Hcl) is available in the market from the year 1999
Actos is also available as Actos met, which is a noble combination of Pioglitazone and Metformin, for better Sugar control.
Pharmacology
The formula of Pioglitazone is C12 H 20 N2 O3 S
White Crystalline powder, which is odour less
The drug is heavily bound to the protein almost 99%
Metabolizes in Liver via Cyp2c8 and is excreted through bile
The half life or the effect of the drug in our body is 4 to 7 hours
Hence can be taken twice daily
Usage/ Indication and Dosage
Actos (pioglitazone) is used in Diabetes Mellitus along with diet and life style modification
Actos is available in the following strengths
Actos 15 mg, Actos 30 mg, Actos 45 mg
The appropriate Dosage will be calculated by your physician
Can be used as mono therapy or in combination with metformin and sulfanylureas
As mono therapy Actos 15 mg is started as once daily dosage, and uptitrated to twice daily, on inadequate control Actos 30 45 mg can be used as once or twice daily regimen
Actos with metformin is available as Actos plus met
Actos can also be used along with sulfanylureas and insulin
The maximum dose of actos available now is 45 mg
Mechanism of Action
Sensitizes insulin and decreases the insulin resistance, Acts via peroxisome proliferator-activated receptor-gamma (PPARγ ) by stimulating the same, The prar gamma receptors are abundantly found in skeletal muscles and adipose tissues They promote the uptake of excess glucose by the skeletal muscles, they also shown to have modulate the cholesterol levels
Side/ Adverse effects of Actos
One of the most commonly seen side effect clinically is fluid retention seen as edema or the swelling of feet. The other un-common undesired effects are URTI, headache, nausea, hypoglycemia, muscle pain and least commonly weight gain
Precaution and contra indication
Not to be given in Congestive heart disease patients, To be used cautiously in patients with the following:
Renal and Hepatic disorders
Pediatric and geriatric age group
Fluctuating sugar levels
In pregnancy and lactation
Where and how to buy Actos
Buying Actos was never been easier and safer than this, Buy Actos from genuine online seller which shows certifications and good testimonials. All you have to do is log in to our web site and register, You can buy generic actos (pioglitazone) 15 mg, 30 mg, 45 mg. After logging in, select the generic or branded Actos along with the strength and quantity. Do not worry even if you dont have a prescription, Our online physicians will take a brief history and issue the prescription.
In emergency you can have generic actos or generic pioglitazone without prescription. Then follow the instructions prompted by the website
We will guarantee you a safe and secure transaction through your online purchase.
Wish you a speedy recovery
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