| Tablet Amaryl (Glimepiride) is an oral hypoglycemic agent (OHA) also called as Anti-diabetic drug (ADA)
Belongs to the class Sulfonylureas (SU)
The IUPAC name of Glimepiride is 3-ethyl-4-methyl-N-(4-[N-((1r,4r)-4-methylcyclohexylcarbamoyl)sulfamoyl]phenethyl)-2-oxo-2,5-dihydro-1H-pyrrole-1-carboxamide.
The brand Amaryl is manufactured by the Sanofi Aventis Pharma Co.
The other brands available or Glimepiride are Glista OD by Cadila, Zoryl,
Amaryl is also available as Amaryl met, which is a noble combination of Glimepiride and Metformin, for better Sugar control.
Pharmacology
The formula of Glimepiride is C24 H 34 N4 O5 S
White Crystalline powder, which is odour less
100% bio-availability
The drug is heavily bound to the protein almost 99%
Metabolizes in Liver and is excreted through urine and feces.
The half life or the effect of the drug in our body is 4 to 7 hours
Hence can be taken twice daily
Usage/ Indication and Dosage
Amaryl (Glimepiride) is used in Diabetes Mellitus along with diet and life style modification
Amaryl is available in the following strengths
Amaryl 1 mg, Amaryl 2 mg, Amaryl 4 mg
The appropriate Dosage will be calculated by your physician
Can be used as mono therapy or in combination with metformin and sulfanylureas
As mono therapy Amaryl 1 mg is started as once daily dosage, and up titrated to twice daily, on inadequate control Amaryl 2 – 4 mg can be used as once or twice daily regimen
Amaryl with metformin is available as Amaryl plus met
Amaryl can also be used along with other OHAs and insulin
The maximum dose of Amaryl available now is 4 mg
Mechanism Of Action
This is an insulin Secretagogue. Blocks the K channel and causes Ca influx leading to release of Insulin, in short stimulates the pancreatic beta cells, promotes the release of insulin.
Side/ Adverse effects of Amaryl
Hypoglycemia, allergic reaction, headache, nausea GI disturbances and least commonly weight gain
Precaution and contra indication
To be used cautiously in patients with the following
-Renal and Hepatic disorders
-Pediatric and geriatric age group
-Hospitalized patients, In chronic illnesses
-Fluctuating sugar levels
- In pregnancy and lactation
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