Calan

Tablet Calan- Verapamil Hcl is an anti hypertensive drug
In common language Calan is a blood pressure medication
Belongs to the group Angiotensin Convering enzyme (ACE) inhibitor
The IUPAC name of Verapamil is (RS)-2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl]-(methyl)amino}-2-prop-2-ylpentanenitrile
The brand Calan is manufactured by the Pfizer pharmaceuticals
The other brands available for Verapamil are Calan SR, Cover- HS, Isotopin SR, Verelan,

Pharmacology of Verapamil Hcl/ Calan

The formula of Verapamil Hcl is C27 H38 N2 O4 Hcl
Physical properties are white crystalline powder, bitter in taste, soluble in water and alcohol
The drug is heavily bound to the protein
Bio-availability is 40%
Gets metabolized in liver, gets excreted by urine.

Usage/ Indication and Dosage of Calan/ Verapamil

Calan (Verapamil besylate) is used for reducing blood pressure along with diet and life style modification
Also used in Angina
In Arrhythmias , Supra ventricular tachycardia
Calan is available in the following strengths and forms
Calan is also available as Sustained release or Calan SR, or Verapamil besylate retard, which releases slowly and gives a linear control in the BP
Calan is available in the market in the following doses
Calan 80 mg, Calan 120 mg, Calan 240 mg, Calan 40 mg.

The appropriate Dosage will be calculated by your physician
Can be used as mono therapy or in combination with other anti-hypertensives monotherapy Calan 80 mg  is started as once daily dosage, and uptitrated to twice daily, on inadequate control Calan 120 mg can be used as once or twice daily regimen
The maximum dose of Calan available now is 240 mg

Mechanism Of Action of Verapamil

Verapamil is a ACE inhibitor other wise also known as angiotensin converting enzyme inhibitor.  As the name implies this inhibits the conversion of ACE I to ACE II, which is potent vaso- constrictor, responsible for the contraction, thereby keeping the cardiac muscle, blood vessel’s wall relaxed, hence by decreasing peripheral resistance, prevents the blood pressure from rising.

Side/ Adverse effects of Calan - Verapamil

Tiredness, fatigue
Orthostatic hypotension
Muscle cramps
Decreased libido
Headache, Nausea, giddiness
Flushing or hot flushes

Precaution and contra indication for Verapamil

In severely hypotensive
If you have a pace maker, or if you have any conduction problem
To be used cautiously in patients with the following
-Renal and Hepatic disorders
-Pediatric age group
-In pregnancy and lactation
-Recent MI, CHF

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