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Generic Drugs vs Branded Drugs - What is the Difference?

Medications are broadly classified into two prime categories Generic and Branded. While branded drugs, also known as 'Innovator Drugs', are highly in demand, many are still skeptical about using generic medications. Probably, they think that generics are poor in quality with no majorhealth benefits. It is absolutely wrong perception. In fact, generics are no different than branded drugs in terms of quality, effect and composition.

Ingredients

The US Food and Drug Administration has givenits green nod to many generic medications only when the agency got convinced of their reliability and strength. Generic and branded drugs are made up of identical ingredients and treat medical conditions in similar way. Generic drugs carries same amount of salts and formulas as that of branded drugs.

Results

Generic and Innovator drugs leave similar effects on human body within same duration of time. If a branded medication takes an hour to improve symptoms, then the generic drugs will give expected results in the same time. Generics take longer to work is a belief that has no significant grounds.

The only difference is Price

Generic medications are cheaper and affordable as compared to branded medications that may blow a hole in your pocket. Companies manufacturing generics do not have to bear the cost of research, new chemical entities and other expenses. Due to low production costs involved, they are priced relatively low and thus, fit into everyone's budget.

Hyzaar

    Product Name+   Price   Buy Now 
 HYZAAR 50mg/12.5mg x 120 Pills   HYZAAR 50mg/12.5mg x 120 Pills   $94.32  Buy Now 
 HYZAAR 50mg/12.5mg x 240 Pills   HYZAAR 50mg/12.5mg x 240 Pills   $188.16  Buy Now 
 HYZAAR 50mg/12.5mg x 90 Pills   HYZAAR 50mg/12.5mg x 90 Pills   $71.19  Buy Now 

Tablet Hyzaar - Losartan + HCTZ potassium is an anti hypertensive drug
Belongs to the group Angiotensin II Receptor Blocker – ARB in combination with Hydrochlorothiazide.
The IUPAC name of Losartan + HCTZ is (2-butyl-4-chloro-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-imidazol-5-yl)methanol.
+ 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
The brand Hyzaar is manufactured by the Merck Healthcare pharmaceuticals
The other brands available for Losartan + HCTZ are anzaplus, Oscaar plus etc etc…
ARBs are also used to reduce protein leak into the urine are also called as nephro- protectors. This is mostly prescribed to Diabetic and hypertensive patients to delay the onset of DM and Hypertensive nephropathy.
This needs to be taken during the day time as in the night it will make you urinate often and may disturb the sleep. Since this increases urine output, during summer you may feel exhausted. Special care to be taken when you go out, or when you go for morning jog.


Pharmacology

The formula of Losartan + HCTZ is C22 H23 CIN6 O + C7 H8 CIN3 O4 S2
Physical properties are white crystalline powder, soluble in water and alcohol
The drug is heavily bound to the protein
Bio-availability is 25-35%
Gets metabolized in liver, gets excreted by urine and bile.
The HCTZ gets absorbed by the GIT and does not metabolize, mostly are excreted in the urine.


Usage/ Indication and Dosage

Hyzaar- Losartan + HCTZ is used as anti hypertensive, along with diet and life style modification
Indicated in Nephropathies especially secondary to DM and BP
Beneficial in BP patients with LVH (left ventricle hypertrophy)
Hyzaar is available in the following strengths and forms
Hyzaar 50-12.5 mg, Hyzaar 100-25mg
Losartan + HCTZ 50-12.5 mg, Losartan + HCTZ  100-25 mg
The appropriate Dosage will be calculated by your physician
Can be used as mono therapy or in combination with other anti-hypertensives monotherapy Hyzaar 50-12.5 mg  is started as once daily dosage, and uptitrated to twice daily, on inadequate control Hyzaar 100-25 mg can be used as once or twice daily regimen or along with other hypertensive medication as HCTZ, beta blockers.
The maximum dose of Hyzaar available now is 100-25 mg


Mechanism Of Action


Losartan + HCTZ is a Angiotensin II Receptor Blocker – ARB. As the name implies this prevents the conversion of angiotensin I to II which is a potent vaso constrictor, which are responsible for the contraction, hence keeping the cardiac muscle, blood vessel’s wall relaxed, hence by decreasing peripheral resistance, prevents the blood pressure from rising.
Hydrochlorothiazide is a diuretic, this blocks the re-absorption of slats like Na and Cl2 from the the distal tubules of kidneys thereby reducing the fluid volume in the ECF or in the blood vessels, which decreases volume load in the vessels thereby controlling blood pressure optimally.
Since this plays around with fluid homeostasis, you have to be very careful about the dosage, with 12.5mg there will not be any Potassium loss, but with higher doses, better to have a prescription from your doctor. Keeping this in mind please do not take potassium supplements with out your physician’s advise


Side/ Adverse effects of Hyzaar - Losartan + HCTZ  


Edema, as bipedal edema
Headache, Nausea, giddiness
Flushing
or hot flushes
As compare to the ACE inhibitors they don’t cause dry cough.


Precaution and contra indication

In severely hypotensive
In IHD and MI
DM2 and hypoglycemia
Dehydrated patients
In AGE or Diarrhea and vomiting
In patients with electrolyte imbalance
To be used cautiously in patients with the following
-Renal and Hepatic disorders
-Pediatric and geriatric age group
- In pregnancy and lactation


Where and how to buy Hyzaar

Buying Hyzaar was never been easier and safer than this
Buy Hyzaar from genuine online seller which shows certifications and good testimonials
All you have to do is log in to our web site and register
You can buy generic Hyzaar- Losartan + HCTZ  50-12.5 mg, 100-25 mg
After logging in, select the generic Hyzaar along with the strength and quantity
Should you have a discount please enter the code in the appropriate column, you will be entitled to get discounted Hyzaar from your next online purchase, get cheapest generic Hyzaar on your monthly refills.
Do not worry even if you don’t have a prescription
Our online physicians will take a brief history and issue the prescription.
In emergency you can have generic Losartan + HCTZ or generic Hyzaar with out prescription
Then follow the instructions prompted by the website
We will guarantee you a safe and secure transaction through your online purchase.

Wish you a speedy recovery
 
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Sundrugstore is an exceptional online pharmacy engaged in the sale and purchase ofgenuine prescription, over-the-counter, generic and branded medications. Since our establishment, we aimed at providingquality medical careto millions of customers at affordable rates and delivering orders in far less time. At Sundrugstore, we are proactively involved in healing lives byensuring quick customer service and addressing queries actively. We have a well built-in structure for storing medications and boast a trained workforce for adequate handling of drugs.

Safety:
Sundrugstore pharmacy ensures complete safety and protection to global customers as we get our supplies from reputed pharmaceutical companies like Pfizer, Merck & Co, Sun Pharma and Cipla. We take immense care by selling only those medications which are FDA-approved and thus, they are fit for consumption.
Affordability:
Sundrugstore provides medications at highly competitive prices and provide exciting discounts on MRP. We give opportunity to save over 80% on every purchase. We never charge anything extra.
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24*7 Customer Support: Sundrugstore pharmacy is committed towards providing high-level customer service. The buyers can place their orders through phone calls, mails or live chat option on the website and we make sure that we meet their requirements in best way possible. Our executives are online 24*7 to answer your queries and grievances.
Cash-back policy: Sundrugstore's staff personally reviews and inspects every order that has to be dispatched. But in case any order misses the deadline or contains wrong or substandard medications, your entire amount will be returned back with no deductions.
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