Lotensin

Tablet Lotensin (Benazepril Hcl is an anti hypertensive drug
In common language Lotensin is a blood pressure medication
Belongs to the group Angiotensin Convering enzyme inhibitor.
This is long acting ACE
The IUPAC name of Benazepril Hcl is 2-[(3S)-3-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}-2-oxo-2,3,4,5-tetrahydro-1H-1-benzazepin-1-yl]acetic acid
The brand Lotensin is manufactured by the the Astra Zeneca pharmaceuticals
The other brands available for Benazepril Hcl are Prinivil, Tensopril by Merck, Hipril by Microlabs
Benazepril Hcl is available in combination with Hydro chlorthiazide as Lotensin HCT, which is a diuretic and anti hypertensive, also available in combination with Amlodipine as Lotrel.

Pharmacology

The formula of Benazepril Hcl is C24 H28 N2 O5 Hcl
Physical properties are white crystalline powder, soluble in water and slightly soluble in alcohol
The drug is heavily bound to the protein
Bio-availability is 40%
Gets metabolized in liver, gets excreted by urine and bile
T ½ is 10 hrs.

Usage/ Indication and Dosage

Lotensin Benazepril Hcl is used as anti hypertensive, along with diet and life style modification
Lotensin is available in the following strengths and forms
Lotensin is available in the market in the following doses
Lotensin 5 mg, Lotensin 10 mg, Lotensin 20 mg, Lotensin 40 mg,
Benazepril Hcl 5mg, Benazepril Hcl 10 mg
The appropriate Dosage will be calculated by your physician
Can be used as mono therapy or in combination with other anti-hypertensives monotherapy Lotensin 5 mg  is started as once daily dosage, and uptitrated to twice daily, on inadequate control Lotensin 10 – 20 mg can be used as once or twice daily regimen
The maximum dose of Lotensin available now is 40 mg

Mechanism Of Action

Benazepril Hcl is a ACE inhibitor other wise also known as angiotensin converting enzyme inhibitor.  As the name implies this inhibits the conversion of ACE I to ACE II, which is potent vaso- constrictor, responsible for the contraction, thereby keeping the cardiac muscle, blood vessel’s wall relaxed, hence by decreasing peripheral resistance, prevents the blood pressure from rising.

Side/ Adverse effects of Lotensin - Benazepril Hcl

Tiredness, fatigue
Orthostatic hypotension
Muscle cramps
Angio edema mostly reported in blacks
Decreased libido
Headache, Nausea, giddiness
Flushing or hot flushes

Precaution and contra indication

In severely hypotensive
In angio-edemas
To be used cautiously in patients with the following
-Renal and Hepatic disorders
-Pediatric and geriatric age group
- In pregnancy and lactation

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