| Capsule Microzide (Hydrochlorothiazide) is an anti hypertensive drug
In common language Microzide is a blood pressure medication or water pill.
Belongs to the group diuretics
The IUPAC name of Hydrochlorothiazide is 6-chloro-3,4-dihydro-2H-1,2,4-benzothiadiazine-7-sulfonamide 1,1-dioxide
The brand Microzide is manufactured by the German Boehringer Ingelheimas pharmaceuticals
The other brands available for Hydrochlorothiazide are Hydrodiuril, Ezide, Hydro-par, Hydrochlorothiazide is mostly available in combination with ACE inhibitors, ARBs…
This needs to be taken during the day time as in the night it will make you urinate often and may disturb the sleep. Since this increases urine output, during summer you may feel exhausted. Special care to be taken when you go out, or when you go for morning jog.
Pharmacology
The formula of Hydrochlorothiazide is C7 H8 CIN3 O4 S2
Physical properties are white crystalline powder, slightly soluble in water.
The HCTZ gets absorbed by the GIT and does not metabolize, mostly are excreted in the urine.
Usage/ Indication and Dosage
Microzide (Hydrochlorothiazide) is used as anti hypertensive, along with diet and life style modification
Microzide is available in the market in the following doses
Microzide 12.5 mg, Microzide 25 mg, Microzide 50,
The appropriate Dosage will be calculated by your physician
Mechanism Of Action
Hydrochlorothiazide is a diuretic, this blocks the re-absorption of slats like Na and Cl2 from the the distal tubules of kidneys thereby reducing the fluid volume in the ECF or in the blood vessels, which decreases volume load in the vessels thereby controlling blood pressure optimally.
Since this plays around with fluid homeostasis, you have to be very careful about the dosage, with 12.5mg there will not be any Potassium loss, but with higher doses, better to have a prescription from your doctor. Keeping this in mind please do not take potassium supplements with out your physician’s advise.
Side/ Adverse effects of Microzide - Hydrochlorothiazide
Tiredness, fatigue
Orthostatic hypotension
Muscle cramps
Headache, Nausea, giddiness
Flushing or hot flushes
Precaution and contra indication
In severely hypotensive
DM2 and hypoglycemia
Dehydrated patients
In AGE or Diarrhea and vomiting
In patients with electrolyte imbalance
To be used cautiously in patients with the following
-Renal and Hepatic disorders
-Pediatric and geriatric age group
- In pregnancy and lactation
Where and how to buy Microzide
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