Norvasc

Tablet Norvasc (Amlodipine besylate) is an anti hypertensive drug
Belongs to the group Calcium Channel blocker
This is long acting CCB
The IUPAC name of Amlodipine is (RS)-3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate
The brand Norvasc is manufactured by the the Pfizer Healthcare pharmaceuticals
Here amlodipine is available as besylate, but it can be found in in either meylate or maleate form.
The other brands available for Amlodipine are Perivasc, Istin, Agen, Amlodine, Amlong, Lopin and Hipril etc etc…
Amlodipine is available in combination with atenelol, benazepril, torvastatin, losartan, lisinopril etc etc…

Pharmacology

The formula of Amlodipine is C20 H25 CIN2 O5 S
Physical properties are white crystalline powder, slightly soluble in water and alcohol
The drug is heavily bound to the protein
Bio-availability is 65- 90%
Gets metabolized in liver, gets excreted by urine.

Usage/ Indication and Dosage

Norvasc (Amlodipine besylate) is used as anti hypertensive, anti- anginal, along with diet and life style modification
Norvasc is available in the following strengths and forms
Norvasc is also available as Sustained release or Norvasc SR, or Amlodipine besylate retard, which releases slowly and gives a linear control in the BP
Norvasc 2.5 mg, Norvasc 5 mg, Norvasc 10 mg
Amlodipine besylate 5mg, Amlodipine besylate 10 mg
The appropriate Dosage will be calculated by your physician
Can be used as mono therapy or in combination with other anti-hypertensives monotherapy Norvasc 2.5 mg  is started as once daily dosage, and uptitrated to twice daily, on inadequate control Norvasc 5 – 10 mg can be used as once or twice daily regimen
The maximum dose of Norvasc available now is 10 mg

Mechanism Of Action

Amlodipine is a calcium channel blocker other wise also known as calcium ion antagonist.  As the name implies this prevents the influx of Ca ion into the cell, which are responsible for the contraction, hence keeping the cardiac muscle, blood vessel’s wall relaxed, hence by decreasing peripheral resistance, prevents the blood pressure from rising.

Side/ Adverse effects of Norvasc - Amlodipine besylate

Edema, as bipedal edema
Headache, Nausea, giddiness
Flushing or hot flushes

Precaution and contra indication
In severely hypotensive
In IHD and MI
To be used cautiously in patients with the following
-Renal and Hepatic disorders
-Pediatric and geriatric age group
-Fluctuating sugar levels
- In pregnancy and lactation

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