| Tablet NovoNorm (Repaglinide) is an oral hypoglycemic agent (OHA) also called as Anti-diabetic drug (ADA)
Belongs to the class Meglitinide and also called as Non sulfonylureas.
The IUPAC name of Repaglinide is (S)-(+)-2-ethoxy-4-[2-(3-methyl-1-[2-(piperidin-1-yl)phenyl]butylamino)-2-oxoethyl]benzoic acid
The brand NovoNorm is manufactured by the Novo Nordisk Pharma Co.
The other brands available or Repaglinide are Prandin and Gluconorm.
This is an Insulin secretagogue, acts in the same way as sulfonylureas, but these are comparatively short acting
Pharmacology
The formula of Repaglinide is C27 H36 N2 O4
White to creamish powder
Soluble in water and alcohol
60% bio-availability
The drug is heavily bound to the protein almost 99%
Metabolizes in Liver and is excreted through urine 10% and feces 90%.
T ½ is 1 hr.
Usage/ Indication and Dosage
NovoNorm (Repaglinide) is used in Diabetes Mellitus along with diet and life style modification
NovoNorm is available in the following strengths
NovoNorm 0.5 mg, NovoNorm 1 mg, NovoNorm 2 mg
The appropriate Dosage will be calculated by your physician
Can be used as mono therapy or in combination with metformin and sulfanylureas
As mono therapy NovoNorm 0.5 mg is started as once daily dosage, and up titrated to twice daily, on inadequate control NovoNorm 1- 2 mg can be used as once or twice daily regimen
NovoNorm can also be used along with other OHAs and insulin
The maximum dose of NovoNorm available now is 2 mg
Mechanism Of Action
This is an insulin Secretagogue. Blocks the K channel and causes Ca influx leading to release of Insulin, in short stimulates the pancreatic beta cells, promotes the release of insulin.
Side/ Adverse effects of NovoNorm / Repaglinide
Hypoglycemia, in a lesser extend compare to the SU, allergic reaction, headache, nausea GI disturbances like diarrhea and least commonly weight gain
Precaution and contra indication
To be used cautiously in patients with the following
-Renal and Hepatic disorders
-Pediatric and geriatric age group
-Hospitalized patients, in chronic illnesses
-Fluctuating sugar levels
- In pregnancy and lactation
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