General Information on Prilosec (Omeprazole)
This drug is an antacid, anti- ulcer
The generic name for this drug is Omeprazole.
Belongs to the class Proton Pump Inhibitors
The IUPAC name is (RS)-6-methoxy-2-((4-methoxy-3,5-dimethylpyridin-2-yl) methylsulfinyl)-1H-benzo[d]imidazole
The brand Losec and Prilosec is manufactured and marketed by the the Astra Zeneca pharmaceutical company.
The other brands available are Losec, Antra, Gastroloc, Mopral, Omepral, Zegerid (Santarus) Zegerid OTC (Schering Plough), in India as Omez
The prilosec pill comes in pink and purple color as capsules.
Pharmacology
The formula of Prilosec is C17 H19 N3 O3 S
Physical Properties of Prilosec- Omeprazole is white crystalline powder, insoluble in water, soluble in alcohol, dissolves quickly in acid medium
Has good bio-availability 40- 80%
Bound to protein 95%
Metabolizes in Liver and is excreted 80% in urine, 20% in feces
The half life or the effect of the drug in our body is 1 hour, duration of action is for 24 hours
Hence can be taken once daily
Usage/ Indication and Dosage
Prilosec is available in the following strengths
Generic Prilosec omeprazole 10 mg, 20 mg and Prilosec 40 mg or Lansoprazole 40 mg
The appropriate Dosage will be calculated by your physician depending upon your condition
The maximum dose of Prilosec available now is 40 mg
The indications are viz;
Acid peptic disease,
gastric Ulcer,
Duodenal ulcer,
Heartburn,
In GERD gastro-esophageal reflux disease, which is nothing but the feeling of heat burn and sour taste in your throat after you burp, if happens rarely not an issue though, but if happens regularly, then this is the tablet you should be taking.
In H-Pylori infection, along with the anti-biotic you will be given this drug or better results
When taken along with domperidone, this combination promotes digestion and prevents heartburn.
Treatment is usually for 4- 8 weeks, except for conditions like zollinger Ellison disease, where the acid production in the stomach is always high.
Mechanism of Action
Acts by inhibiting/ stopping the release of acid through Proton Pumps present in the stomachs parietal cell, which are responsible for the acid release.
Side/ Adverse effects of Prilosec
Rashes, allergy reaction, if the patient is allergic to omeprazole and related compounds.
The other un-common undesired effects are drowsiness, headache, nausea, gas trouble, URTI, constipation and rarely infection.
Precaution and contra indication
Hypersensitivity
Pediatric age group
Hepatic and renal disease
Pregnancy B
Malignancy
To be used in caution when patients are taking warfarin
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